Publications
Adolescent onset of volitional ethanol intake normalizes sex differences observed with adult-onset ethanol intake and negative affective behaviors during protracted forced abstinence.
Edwards CM, Xu Z, Winder DG
2025 Oct 7
Psychopharmacology
Adenosine A(2A) Receptors Link Astrocytic α(1)-Adrenergic Signaling to Wake-Promoting Dopamine Neurons.
Petersen N, McCann KE, Stavarache MA, Kim LY, Weinshenker D, Winder DG
2025 May 1
Biological psychiatry
A Novel Mouse Home Cage Lickometer System Reveals Sex- and Housing-Based Influences on Alcohol Drinking.
Petersen N, Adank DN, Quan Y, Edwards CM, Hallal SD, Taylor A, Winder DG, Doyle MA
2024 Oct
eNeuro
Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking.
Yoon HJ, Doyle MA, Altemus ME, Bethi R, Lago SH, Winder DG, Calipari ES
2025 Mar
Alcohol (Fayetteville, N.Y.)
Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence.
Zabik NL, Flook EA, Feola B, Benningfield MM, Silveri MM, Winder DG, Blackford JU
2024 Sep
Alcohol, clinical & experimental research
BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.
Doyle MA, Salimando GJ, Altemus ME, Badt JK, Bedenbaugh MN, Vardy AS, Adank DN, Park AS, Winder DG
2024 Oct
Alcohol, clinical & experimental research
Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity.
Nabit BP, Taylor A, Winder DG
2024 Jul 31
The Journal of neuroscience : the official journal of the Society for Neuroscience
A Cocaine-Activated Ensemble Exerts Increased Control Over Behavior While Decreasing in Size.
Thibeault KC, Leonard MZ, Kondev V, Emerson SD, Bethi R, Lopez AJ, Sens JP, Nabit BP, Elam HB, Winder DG, Patel S, Kiraly DD, Grueter BA, Calipari ES
2025 Mar 15
Biological psychiatry
A master regulator of opioid reward in the ventral prefrontal cortex.
Smith ACW, Ghoshal S, Centanni SW, Heyer MP, Corona A, Wills L, Andraka E, Lei Y, O'Connor RM, Caligiuri SPB, Khan S, Beaumont K, Sebra RP, Kieffer BL, Winder DG, Ishikawa M, Kenny PJ
2024 Jun 7
Science (New York, N.Y.)
A novel mouse home cage lickometer system reveals sex- and housing-based influences on alcohol drinking.
Petersen N, Adank DN, Quan Y, Edwards CM, Taylor A, Winder DG, Doyle MA
2024 May 23
bioRxiv : the preprint server for biology
BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.
Doyle MA, Salimando GJ, Altemus ME, Badt JK, Bedenbaugh MN, Vardy AS, Adank DN, Park AS, Winder DG
2024 Apr 21
bioRxiv : the preprint server for biology
Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.
Doyle MA, Taylor A, Winder DG
2025
Current topics in behavioral neurosciences
Forced Abstinence from Volitional Ethanol Intake Drives a Vulnerable Period of Hyperexcitability in BNST-Projecting Insular Cortex Neurons.
Taylor A, Adank DN, Young PA, Quan Y, Nabit BP, Winder DG
2024 Jan 24
The Journal of neuroscience : the official journal of the Society for Neuroscience
Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons.
Kondev V, Najeed M, Loomba N, Brown J, Winder DG, Grueter BA, Patel S
2023 Aug 22
Proceedings of the National Academy of Sciences of the United States of America
LIQ HD (Lick Instance Quantifier Home Cage Device): An Open-Source Tool for Recording Undisturbed Two-Bottle Drinking Behavior in a Home Cage Environment.
Petersen N, Adank DN, Raghavan R, Winder DG, Doyle MA
2023 Apr
eNeuro
BNST PKCδ neurons are activated by specific aversive conditions to promote anxiety-like behavior.
Williford KM, Taylor A, Melchior JR, Yoon HJ, Sale E, Negasi MD, Adank DN, Brown JA, Bedenbaugh MN, Luchsinger JR, Centanni SW, Patel S, Calipari ES, Simerly RB, Winder DG
2023 Jun
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder.
Flook EA, Feola B, Benningfield MM, Silveri MM, Winder DG, Blackford JU
2023 May 9
Alcohol and alcoholism (Oxford, Oxfordshire)
GluN2D expression is regulated by restraint stress and supports active stress coping bouts.
Doyle MA, Brown JA, Winder DG
2023 Mar 1
Neuropharmacology
An ensemble recruited by α(2a)-adrenergic receptors is engaged in a stressor-specific manner in mice.
Brown JA, Petersen N, Centanni SW, Jin AY, Yoon HJ, Cajigas SA, Bedenbaugh MN, Luchsinger JR, Patel S, Calipari ES, Simerly RB, Winder DG
2023 Jul
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
High fat diet blunts stress-induced hypophagia and activation of Glp1r dorsal lateral septum neurons in male but not in female mice.
Bales MB, Centanni SW, Luchsinger JR, Fathi P, Biddinger JE, Le TDV, Nwaba KG, Paldrmic IM, Winder DG, Ayala JE
2022 Oct
Molecular metabolism
Prefrontal cortex parvalbumin interneurons exhibit decreased excitability and potentiated synaptic strength after ethanol reward learning.
Ferranti AS, Johnson KA, Winder DG, Conn PJ, Joffe ME
2022 Jun
Alcohol (Fayetteville, N.Y.)
Acute restraint stress redirects prefrontal cortex circuit function through mGlu(5) receptor plasticity on somatostatin-expressing interneurons.
Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ
2022 Mar 16
Neuron
The impact of intermittent exercise on mouse ethanol drinking and abstinence-associated affective behavior and physiology.
Centanni SW, Conley SY, Luchsinger JR, Lantier L, Winder DG
2022 Jan
Alcoholism, clinical and experimental research
Danger and distress: Parabrachial-extended amygdala circuits.
Jaramillo AA, Brown JA, Winder DG
2021 Oct 15
Neuropharmacology
Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models.
Winters ND, Bedse G, Astafyev AA, Patrick TA, Altemus M, Morgan AJ, Mukerjee S, Johnson KD, Mahajan VR, Uddin MJ, Kingsley PJ, Centanni SW, Siciliano CA, Samuels DC, Marnett LJ, Winder DG, Patel S
2021 Jul 22
The Journal of clinical investigation
Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice.
Luchsinger JR, Fetterly TL, Williford KM, Salimando GJ, Doyle MA, Maldonado J, Simerly RB, Winder DG, Centanni SW
2021 Jun 11
Nature communications
Cocaine Augments Dopamine-Mediated Inhibition of Neuronal Activity in the Dorsal Bed Nucleus of the Stria Terminalis.
Melchior JR, Perez RE, Salimando GJ, Luchsinger JR, Basu A, Winder DG
2021 Jul 7
The Journal of neuroscience : the official journal of the Society for Neuroscience
Alterations in connectivity of the bed nucleus of the stria terminalis during early abstinence in individuals with alcohol use disorder.
Flook EA, Feola B, Benningfield MM, Silveri MM, Winder DG, Blackford JU
2021 May
Alcoholism, clinical and experimental research
Increased Synaptic Strength and mGlu(2/3) Receptor Plasticity on Mouse Prefrontal Cortex Intratelencephalic Pyramidal Cells Following Intermittent Access to Ethanol.
Joffe ME, Winder DG, Conn PJ
2021 Mar
Alcoholism, clinical and experimental research
BNST transient activity associates with approach behavior in a stressful environment and is modulated by the parabrachial nucleus.
Jaramillo AA, Williford KM, Marshall C, Winder DG, Centanni SW
2020 Nov
Neurobiology of stress
Contrasting sex-dependent adaptations to synaptic physiology and membrane properties of prefrontal cortex interneuron subtypes in a mouse model of binge drinking.
Joffe ME, Winder DG, Conn PJ
2020 Nov 1
Neuropharmacology
BNST GluN2D-Containing NMDA Receptors Influence Anxiety- and Depressive-like Behaviors and ModulateCell-Specific Excitatory/Inhibitory Synaptic Balance.
Salimando GJ, Hyun M, Boyt KM, Winder DG
2020 May 13
The Journal of neuroscience : the official journal of the Society for Neuroscience
α(2A)-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference.
Perez RE, Basu A, Nabit BP, Harris NA, Folkes OM, Patel S, Gilsbach R, Hein L, Winder DG
2020 Aug
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.
Flook EA, Luchsinger JR, Silveri MM, Winder DG, Benningfield MM, Blackford JU
2021 Mar
Addiction biology
BNST-insula structural connectivity in humans.
Flook EA, Feola B, Avery SN, Winder DG, Woodward ND, Heckers S, Blackford JU
2020 Apr 15
NeuroImage
mGlu(2) and mGlu(3) Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.
Joffe ME, Santiago CI, Oliver KH, Maksymetz J, Harris NA, Engers JL, Lindsley CW, Winder DG, Conn PJ
2020 Jan 8
Neuron
Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states.
Hartley ND, Gaulden AD, Báldi R, Winters ND, Salimando GJ, Rosas-Vidal LE, Jameson A, Winder DG, Patel S
2019 Dec
Nature neuroscience
Driving the Downward Spiral: Alcohol-Induced Dysregulation of Extended Amygdala Circuits and Negative Affect.
Centanni SW, Bedse G, Patel S, Winder DG
2019 Oct
Alcoholism, clinical and experimental research
Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder.
Bedse G, Centanni SW, Winder DG, Patel S
2019 Oct
Alcoholism, clinical and experimental research
Acute Negative Allosteric Modulation of M(5) Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with No Effect on Antinociception.
Gould RW, Gunter BW, Bubser M, Matthews RT, Teal LB, Ragland MG, Bridges TM, Garrison AT, Winder DG, Lindsley CW, Jones CK
2019 Aug 21
ACS chemical neuroscience
Chronic Intermittent Ethanol and Acute Stress Similarly Modulate BNST CRF Neuron Activity via Noradrenergic Signaling.
Snyder AE, Salimando GJ, Winder DG, Silberman Y
2019 Aug
Alcoholism, clinical and experimental research
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE
2019 Feb 19
Science signaling
α(2A)-Adrenergic Receptor Activation Decreases Parabrachial Nucleus Excitatory Drive onto BNST CRF Neurons and Reduces Their Activity In Vivo.
Fetterly TL, Basu A, Nabit BP, Awad E, Williford KM, Centanni SW, Matthews RT, Silberman Y, Winder DG
2019 Jan 16
The Journal of neuroscience : the official journal of the Society for Neuroscience
Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence.
Centanni SW, Morris BD, Luchsinger JR, Bedse G, Fetterly TL, Patel S, Winder DG
2019 Feb
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Noradrenergic Transmission at Alpha1-Adrenergic Receptors in the Ventral Periaqueductal Gray Modulates Arousal.
Porter-Stransky KA, Centanni SW, Karne SL, Odil LM, Fekir S, Wong JC, Jerome C, Mitchell HA, Escayg A, Pedersen NP, Winder DG, Mitrano DA, Weinshenker D
2019 Feb 1
Biological psychiatry
Dorsal BNST α(2A)-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Harris NA, Isaac AT, Günther A, Merkel K, Melchior J, Xu M, Eguakun E, Perez R, Nabit BP, Flavin S, Gilsbach R, Shonesy B, Hein L, Abel T, Baumann A, Matthews R, Centanni SW, Winder DG
2018 Oct 17
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ketamine administration during a critical period after forced ethanol abstinence inhibits the development of time-dependent affective disturbances.
Vranjkovic O, Winkler G, Winder DG
2018 Aug
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors.
Harris NA, Winder DG
2018 Sep 19
ACS chemical neuroscience
Metabotropic Glutamate Receptors in Alcohol Use Disorder: Physiology, Plasticity, and Promising Pharmacotherapies.
Joffe ME, Centanni SW, Jaramillo AA, Winder DG, Conn PJ
2018 Sep 19
ACS chemical neuroscience
Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning.
Bergstrom HC, Lipkin AM, Lieberman AG, Pinard CR, Gunduz-Cinar O, Brockway ET, Taylor WW, Nonaka M, Bukalo O, Wills TA, Rubio FJ, Li X, Pickens CL, Winder DG, Holmes A
2018 May 22
Cell reports
Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.
Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ
2018 Aug 15
Biological psychiatry
The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?
Pomrenze MB, Fetterly TL, Winder DG, Messing RO
2017 Dec
Alcoholism, clinical and experimental research
The bed nucleus of the stria terminalis in drug-associated behavior and affect: A circuit-based perspective.
Vranjkovic O, Pina M, Kash TL, Winder DG
2017 Aug 1
Neuropharmacology
Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.
Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S
2017 Mar 28
Nature communications
Preclinical voluntary drinking models for alcohol abstinence-induced affective disturbances in mice.
Holleran KM, Winder DG
2017 Jan
Genes, brain, and behavior
Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure.
Swartzwelder HS, Risher ML, Miller KM, Colbran RJ, Winder DG, Wills TA
2016
PloS one
Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking.
Holleran KM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LE, Patel S, Winder DG
2016 Jul
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates group I mGlu receptor-dependent long-term depression.
Wills TA, Baucum AJ 2nd, Holleran KM, Chen Y, Pasek JG, Delpire E, Tabb DL, Colbran RJ, Winder DG
2017 Mar
Addiction biology
Ethanol produces corticotropin-releasing factor receptor-dependent enhancement of spontaneous glutamatergic transmission in the mouse central amygdala.
Silberman Y, Fetterly TL, Awad EK, Milano EJ, Usdin TB, Winder DG
2015 Nov
Alcoholism, clinical and experimental research
The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models.
Patel S, Shonesy BC, Bluett RJ, Winder DG, Colbran RJ
2016 May 15
Biological psychiatry
Ethanol and corticotropin releasing factor receptor modulation of central amygdala neurocircuitry: An update and future directions.
Silberman Y, Winder DG
2015 May
Alcohol (Fayetteville, N.Y.)
The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium.
Shonesy BC, Winder DG, Patel S, Colbran RJ
2015 Apr
Neuropharmacology
Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation.
Shonesy BC, Bluett RJ, Ramikie TS, Báldi R, Hermanson DJ, Kingsley PJ, Marnett LJ, Winder DG, Colbran RJ, Patel S
2014 Dec 11
Cell reports
Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner.
Williams MA, Li C, Kash TL, Matthews RT, Winder DG
2014 Nov
Neuropharmacology
α(2A)-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalis.
Flavin SA, Matthews RT, Wang Q, Muly EC, Winder DG
2014 Jul 9
The Journal of neuroscience : the official journal of the Society for Neuroscience
Systems-level view of cocaine addiction: the interconnection of the immune and nervous systems.
Marasco CC, Goodwin CR, Winder DG, Schramm-Sapyta NL, McLean JA, Wikswo JP
2014 Nov
Experimental biology and medicine (Maywood, N.J.)
BNST neurocircuitry in humans.
Avery SN, Clauss JA, Winder DG, Woodward N, Heckers S, Blackford JU
2014 May 1
NeuroImage
Knockdown of BNST GluN2B-containing NMDA receptors mimics the actions of ketamine on novelty-induced hypophagia.
Louderback KM, Wills TA, Muglia LJ, Winder DG
2013 Dec 3
Translational psychiatry
Developmental changes in the acute ethanol sensitivity of glutamatergic and GABAergic transmission in the BNST.
Wills TA, Kash TL, Winder DG
2013 Nov
Alcohol (Fayetteville, N.Y.)
CaMKII is essential for the proasthmatic effects of oxidation.
Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME
2013 Jul 24
Science translational medicine
Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward.
Silberman Y, Winder DG
2013
Frontiers in psychiatry
CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.
Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ 2nd, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ
2013 Apr
Nature neuroscience
Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
Silberman Y, Winder DG
2013 Jul
Neuropharmacology
Noradrenergic control of the bed nucleus of the stria terminalis in stress and reward.
Flavin SA, Winder DG
2013 Jul
Neuropharmacology
Ethanol effects on N-methyl-D-aspartate receptors in the bed nucleus of the stria terminalis.
Wills TA, Winder DG
2013 Apr 1
Cold Spring Harbor perspectives in medicine
A corticotropin releasing factor pathway for ethanol regulation of the ventral tegmental area in the bed nucleus of the stria terminalis.
Silberman Y, Matthews RT, Winder DG
2013 Jan 16
The Journal of neuroscience : the official journal of the Society for Neuroscience
Assessment of the impact of pattern of cocaine dosing schedule during conditioning and reconditioning on magnitude of cocaine CPP, extinction, and reinstatement.
Conrad KL, Louderback KM, Milano EJ, Winder DG
2013 May
Psychopharmacology
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG
2012
PloS one
Absence of Ca2+-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory.
Wieczorek L, Majumdar D, Wills TA, Hu L, Winder DG, Webb DJ, Muglia LJ
2012 May 29
Translational psychiatry
Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes.
Conrad KL, Davis AR, Silberman Y, Sheffler DJ, Shields AD, Saleh SA, Sen N, Matthies HJ, Javitch JA, Lindsley CW, Winder DG
2012 Sep
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound.
Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW
2012 Mar 5
ChemMedChem
Stimulus dynamics increase the self-administration of compound visual and auditory stimuli.
Olsen CM, Winder DG
2012 Mar 5
Neuroscience letters
GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.
Wills TA, Klug JR, Silberman Y, Baucum AJ, Weitlauf C, Colbran RJ, Delpire E, Winder DG
2012 Jan 31
Proceedings of the National Academy of Sciences of the United States of America
(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.
Lindsley CW, Bates BS, Menon UN, Jadhav SB, Kane AS, Jones CK, Rodriguez AL, Conn PJ, Olsen CM, Winder DG, Emmitte KA
2011 Aug 17
ACS chemical neuroscience
Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent mice.
Gustin RM, Shonesy BC, Robinson SL, Rentz TJ, Baucum AJ 2nd, Jalan-Sakrikar N, Winder DG, Stanwood GD, Colbran RJ
2011 Aug
Molecular and cellular neurosciences
mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.
Gosnell HB, Silberman Y, Grueter BA, Duvoisin RM, Raber J, Winder DG
2011 Jul
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Stress-induced alterations in anxiety-like behavior and adaptations in plasticity in the bed nucleus of the stria terminalis.
Conrad KL, Louderback KM, Gessner CP, Winder DG
2011 Aug 3
Physiology & behavior
Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges.
Duvoisin RM, Villasana L, Davis MJ, Winder DG, Raber J
2011 Aug 1
Behavioural brain research
β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
Nobis WP, Kash TL, Silberman Y, Winder DG
2011 Jun 1
Biological psychiatry
Altered anxiety-like behavior and long-term potentiation in the bed nucleus of the stria terminalis in adult mice exposed to chronic social isolation, unpredictable stress, and ethanol beginning in adolescence.
Conrad KL, Winder DG
2011 Sep
Alcohol (Fayetteville, N.Y.)
Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).
Olsen CM, Childs DS, Stanwood GD, Winder DG
2010 Nov 30
PloS one
Operant sensation seeking in the mouse.
Olsen CM, Winder DG
2010 Nov 10
Journal of visualized experiments : JoVE
An odyssey of fear: Homer stresses new mechanisms.
Patel S, Winder DG
2010 Dec 1
Biological psychiatry
Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability.
Mozhui K, Karlsson RM, Kash TL, Ihne J, Norcross M, Patel S, Farrell MR, Hill EE, Graybeal C, Martin KP, Camp M, Fitzgerald PJ, Ciobanu DC, Sprengel R, Mishina M, Wellman CL, Winder DG, Williams RW, Holmes A
2010 Apr 14
The Journal of neuroscience : the official journal of the Society for Neuroscience
Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.
McElligott ZA, Klug JR, Nobis WP, Patel S, Grueter BA, Kash TL, Winder DG
2010 Feb 2
Proceedings of the National Academy of Sciences of the United States of America
Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.
Patel S, Kingsley PJ, Mackie K, Marnett LJ, Winder DG
2009 Dec
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis.
Kash TL, Baucum AJ 2nd, Conrad KL, Colbran RJ, Winder DG
2009 Oct
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Subcellular localization of the antidepressant-sensitive norepinephrine transporter.
Matthies HJ, Han Q, Shields A, Wright J, Moore JL, Winder DG, Galli A, Blakely RD
2009 Jun 23
BMC neuroscience
alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis.
Shields AD, Wang Q, Winder DG
2009 Sep 29
Neuroscience
Modulation of glutamatergic synaptic transmission in the bed nucleus of the stria terminalis.
McElligott ZA, Winder DG
2009 Nov 13
Progress in neuro-psychopharmacology & biological psychiatry