Publications
Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity
Nabit BP, Taylor A, Winder DG.
Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine
Winder DG, Conn PJ.
Oxidation of calmodulin alters activation and regulation of CaMKII
Robison AJ, Winder DG, Colbran RJ, Bartlett RK.
Yohimbine impairs extinction of cocaine-conditioned place preference in an alpha2-adrenergic receptor independent process
Davis AR, Shields AD, Brigman JL, Norcross M, McElligott ZA, Holmes A, Winder DG.
Stress-induced alterations in anxiety-like behavior and adaptations in plasticity in the bed nucleus of the stria terminalis
Conrad KL, Louderback KM, Gessner CP, Winder DG.
Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior
Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ.
A Cocaine-Activated Ensemble Exerts Increased Control Over Behavior While Decreasing in Size
Thibeault KC, Leonard MZ, Kondev V, Emerson SD, Bethi R, Lopez AJ, Sens JP, Nabit BP, Elam HB, Winder DG, Patel S, Kiraly DD, Grueter BA, Calipari ES.
Activation of metabotropic glutamate receptors in the hippocampus increases cyclic AMP accumulation
Winder DG, Conn PJ.
Acute Negative Allosteric Modulation of M(5) Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with No Effect on Antinociception
Gould RW, Gunter BW, Bubser M, Matthews RT, Teal LB, Ragland MG, Bridges TM, Garrison AT, Winder DG, Lindsley CW, Jones CK.
Absence of Ca2+-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory
Wieczorek L, Majumdar D, Wills TA, Hu L, Winder DG, Webb DJ, Muglia LJ.
A novel mouse brain slice preparation of the hippocampo-accumbens pathway
Matthews RT, Coker O, Winder DG.
Ethanol effects on N-methyl-D-aspartate receptors in the bed nucleus of the stria terminalis
Wills TA, Winder DG.
Dorsal BNST α(2A)-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors
Harris NA, Isaac AT, Günther A, Merkel K, Melchior J, Xu M, Eguakun E, Perez R, Nabit BP, Flavin S, Gilsbach R, Shonesy B, Hein L, Abel T, Baumann A, Matthews R, Centanni SW, Winder DG.
BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice
Doyle MA, Salimando GJ, Altemus ME, Badt JK, Bedenbaugh MN, Vardy AS, Adank DN, Park AS, Winder DG.
Forced Abstinence from Volitional Ethanol Intake Drives a Vulnerable Period of Hyperexcitability in BNST-Projecting Insular Cortex Neurons
Taylor A, Adank DN, Young PA, Quan Y, Nabit BP, Winder DG.
A corticotropin releasing factor pathway for ethanol regulation of the ventral tegmental area in the bed nucleus of the stria terminalis
Silberman Y, Matthews RT, Winder DG.
LTP in the mouse nucleus accumbens is developmentally regulated
Schramm NL, Egli RE, Winder DG.
α(2A)-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference
Perez RE, Basu A, Nabit BP, Harris NA, Folkes OM, Patel S, Gilsbach R, Hein L, Winder DG.
High-frequency stimulation induces ethanol-sensitive long-term potentiation at glutamatergic synapses in the dorsolateral bed nucleus of the stria terminalis
Weitlauf C, Egli RE, Grueter BA, Winder DG.
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors
Vanhoose AM, Clements JM, Winder DG.
Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice
Schramm-Sapyta NL, Pratt AR, Winder DG.
ERK activation by G-protein-coupled receptors in mouse brain is receptor identity-specific
Vanhoose AM, Emery M, Jimenez L, Winder DG.
Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum
Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG.
Chronic Intermittent Ethanol and Acute Stress Similarly Modulate BNST CRF Neuron Activity via Noradrenergic Signaling
Snyder AE, Salimando GJ, Winder DG, Silberman Y.
Roles of serine/threonine phosphatases in hippocampal synaptic plasticity
Winder DG, Sweatt JD.
Adenosine A(2A) Receptors Link Astrocytic α(1)-Adrenergic Signaling to Wake-Promoting Dopamine Neurons
Petersen N, McCann KE, Stavarache MA, Kim LY, Weinshenker D, Winder DG.
Stimulus dynamics increase the self-administration of compound visual and auditory stimuli
Olsen CM, Winder DG.
A novel mouse home cage lickometer system reveals sex- and housing-based influences on alcohol drinking
Petersen N, Adank DN, Quan Y, Edwards CM, Taylor A, Winder DG, Doyle MA.
Knockdown of BNST GluN2B-containing NMDA receptors mimics the actions of ketamine on novelty-induced hypophagia
Louderback KM, Wills TA, Muglia LJ, Winder DG.
High fat diet blunts stress-induced hypophagia and activation of Glp1r dorsal lateral septum neurons in male but not in female mice
Bales MB, Centanni SW, Luchsinger JR, Fathi P, Biddinger JE, Le TDV, Nwaba KG, Paldrmic IM, Winder DG, Ayala JE.
Dorsal and ventral distribution of excitable and synaptic properties of neurons of the bed nucleus of the stria terminalis
Egli RE, Winder DG.
CaMKII is essential for the proasthmatic effects of oxidation
Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME.
Group I mGluRs and long-term depression: potential roles in addiction?
Grueter BA, McElligott ZA, Winder DG.
Amygdala kindling alters protein kinase C activity in dentate gyrus
Chen SJ, Desai MA, Klann E, Winder DG, Sweatt JD, Conn PJ.
Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis
Kash TL, Winder DG.
Metabotropic Glutamate Receptors in Alcohol Use Disorder: Physiology, Plasticity, and Promising Pharmacotherapies
Joffe ME, Centanni SW, Jaramillo AA, Winder DG, Conn PJ.
Adolescent onset of volitional ethanol intake normalizes sex differences observed with adult-onset ethanol intake and negative affective behaviors during protracted forced abstinence
Edwards CM, Xu Z, Winder DG.
CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ 2nd, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ.
Driving the Downward Spiral: Alcohol-Induced Dysregulation of Extended Amygdala Circuits and Negative Affect
Centanni SW, Bedse G, Patel S, Winder DG.
Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking
Yoon HJ, Doyle MA, Altemus ME, Bethi R, Lago SH, Winder DG, Calipari ES.
Preclinical voluntary drinking models for alcohol abstinence-induced affective disturbances in mice
Holleran KM, Winder DG.
Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice
Olsen CM, Winder DG.
Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking
Holleran KM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LE, Patel S, Winder DG.
Alterations in connectivity of the bed nucleus of the stria terminalis during early abstinence in individuals with alcohol use disorder
Flook EA, Feola B, Benningfield MM, Silveri MM, Winder DG, Blackford JU.
A potassium channel blocker induces a long-lasting enhancement of corticostriatal responses
Norman ED, Egli RE, Colbran RJ, Winder DG.
Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala
Silberman Y, Winder DG.
α(2A)-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalis
Flavin SA, Matthews RT, Wang Q, Muly EC, Winder DG.
Systems-level view of cocaine addiction: the interconnection of the immune and nervous systems
Marasco CC, Goodwin CR, Winder DG, Schramm-Sapyta NL, McLean JA, Wikswo JP.
A method for single-session cocaine self-administration in the mouse
Olsen CM, Winder DG.
The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target?
Pomrenze MB, Fetterly TL, Winder DG, Messing RO.
GluN2D expression is regulated by restraint stress and supports active stress coping bouts
Doyle MA, Brown JA, Winder DG.
The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models
Patel S, Shonesy BC, Bluett RJ, Winder DG, Colbran RJ.
Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice
Vanhoose AM, Ritchie MD, Winder DG.
Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin
Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER.
Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders
McElligott ZA, Winder DG.
Altered anxiety-like behavior and long-term potentiation in the bed nucleus of the stria terminalis in adult mice exposed to chronic social isolation, unpredictable stress, and ethanol beginning in adolescence
Conrad KL, Winder DG.
Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses
Macek TA, Winder DG, Gereau RW 4th, Ladd CO, Conn PJ.
Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure
Swartzwelder HS, Risher ML, Miller KM, Colbran RJ, Winder DG, Wills TA.
Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus
Winder DG, Ritch PS, Gereau RW 4th, Conn PJ.
BNST transient activity associates with approach behavior in a stressful environment and is modulated by the parabrachial nucleus
Jaramillo AA, Williford KM, Marshall C, Winder DG, Centanni SW.
NMDA and beta1-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampus
Vanhoose AM, Winder DG.
Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states
Hartley ND, Gaulden AD, Báldi R, Winters ND, Salimando GJ, Rosas-Vidal LE, Jameson A, Winder DG, Patel S.
Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell
Schramm-Sapyta NL, Olsen CM, Winder DG.
Inducible and reversible gene expression with the rtTA system for the study of memory
Mansuy IM, Winder DG, Moallem TM, Osman M, Mayford M, Hawkins RD, Kandel ER.
Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis
Kash TL, Matthews RT, Winder DG.
BNST GluN2D-Containing NMDA Receptors Influence Anxiety- and Depressive-like Behaviors and ModulateCell-Specific Excitatory/Inhibitory Synaptic Balance
Salimando GJ, Hyun M, Boyt KM, Winder DG.
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability
Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG.
Ketamine administration during a critical period after forced ethanol abstinence inhibits the development of time-dependent affective disturbances
Vranjkovic O, Winkler G, Winder DG.
ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors
Winder DG, Martin KC, Muzzio IA, Rohrer D, Chruscinski A, Kobilka B, Kandel ER.
Endocannabinoid signalling modulates susceptibility to traumatic stress exposure
Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S.
Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization
Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q.
Increased Synaptic Strength and mGlu(2/3) Receptor Plasticity on Mouse Prefrontal Cortex Intratelencephalic Pyramidal Cells Following Intermittent Access to Ethanol
Joffe ME, Winder DG, Conn PJ.
Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates group I mGlu receptor-dependent long-term depression
Wills TA, Baucum AJ 2nd, Holleran KM, Chen Y, Pasek JG, Delpire E, Tabb DL, Colbran RJ, Winder DG.
Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes
Conrad KL, Davis AR, Silberman Y, Sheffler DJ, Shields AD, Saleh SA, Sen N, Matthies HJ, Javitch JA, Lindsley CW, Winder DG.
Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala
Patel S, Kingsley PJ, Mackie K, Marnett LJ, Winder DG.
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane-1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices
Chung DS, Winder DG, Conn PJ.
Cocaine Augments Dopamine-Mediated Inhibition of Neuronal Activity in the Dorsal Bed Nucleus of the Stria Terminalis
Melchior JR, Perez RE, Salimando GJ, Luchsinger JR, Basu A, Winder DG.
BNST-insula structural connectivity in humans
Flook EA, Feola B, Avery SN, Winder DG, Woodward ND, Heckers S, Blackford JU.
Danger and distress: Parabrachial-extended amygdala circuits
Jaramillo AA, Brown JA, Winder DG.
Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration
Grueter BA, Gosnell HB, Olsen CM, Schramm-Sapyta NL, Nekrasova T, Landreth GE, Winder DG.
Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence
Zabik NL, Flook EA, Feola B, Benningfield MM, Silveri MM, Winder DG, Blackford JU.
Noradrenergic Transmission at Alpha1-Adrenergic Receptors in the Ventral Periaqueductal Gray Modulates Arousal
Porter-Stransky KA, Centanni SW, Karne SL, Odil LM, Fekir S, Wong JC, Jerome C, Mitchell HA, Escayg A, Pedersen NP, Winder DG, Mitrano DA, Weinshenker D.
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound
Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, Olsen CM, Winder DG, Emmitte KA, Lindsley CW.
Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
Weitlauf C, Honse Y, Auberson YP, Mishina M, Lovinger DM, Winder DG.
β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism
Nobis WP, Kash TL, Silberman Y, Winder DG.
Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation
Shonesy BC, Bluett RJ, Ramikie TS, Báldi R, Hermanson DJ, Kingsley PJ, Marnett LJ, Winder DG, Colbran RJ, Patel S.
BNST PKCδ neurons are activated by specific aversive conditions to promote anxiety-like behavior
Williford KM, Taylor A, Melchior JR, Yoon HJ, Sale E, Negasi MD, Adank DN, Brown JA, Bedenbaugh MN, Luchsinger JR, Centanni SW, Patel S, Calipari ES, Simerly RB, Winder DG.
Ethanol produces corticotropin-releasing factor receptor-dependent enhancement of spontaneous glutamatergic transmission in the mouse central amygdala
Silberman Y, Fetterly TL, Awad EK, Milano EJ, Usdin TB, Winder DG.
Contrasting sex-dependent adaptations to synaptic physiology and membrane properties of prefrontal cortex interneuron subtypes in a mouse model of binge drinking
Joffe ME, Winder DG, Conn PJ.
Endocannabinoid Signaling in the Central Amygdala and Bed Nucleus of the Stria Terminalis: Implications for the Pathophysiology and Treatment of Alcohol Use Disorder
Bedse G, Centanni SW, Winder DG, Patel S.
GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis
Wills TA, Klug JR, Silberman Y, Baucum AJ, Weitlauf C, Colbran RJ, Delpire E, Winder DG.
Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication
Winder DG, Conn PJ.
<a href=10.1002/(SICI)1097-4547(19961015)46:23.0.CO;2-I target="_blank" rel="noopener noreferrer" style="text-decoration: underline">10.1002/(SICI)1097-4547(19961015)46:23.0.CO;2-I
Acute restraint stress redirects prefrontal cortex circuit function through mGlu(5) receptor plasticity on somatostatin-expressing interneurons
Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ.
α(2A)-Adrenergic Receptor Activation Decreases Parabrachial Nucleus Excitatory Drive onto BNST CRF Neurons and Reduces Their Activity In Vivo
Fetterly TL, Basu A, Nabit BP, Awad E, Williford KM, Centanni SW, Matthews RT, Silberman Y, Winder DG.
The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium
Shonesy BC, Winder DG, Patel S, Colbran RJ.
Prefrontal cortex parvalbumin interneurons exhibit decreased excitability and potentiated synaptic strength after ethanol reward learning
Ferranti AS, Johnson KA, Winder DG, Conn PJ, Joffe ME.
Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder
Flook EA, Feola B, Benningfield MM, Silveri MM, Winder DG, Blackford JU.